Our experience in treating meningiomas with radiosurgery

Introduction: Radiosurgery is ionizing radiation treatment. Concentration of a large amount in an area ​​the brain results ablation the lesion. The technique was designed and perfected by Dr. Lars Lexell, Swedish neurosurgeon, 1951. Meningiomas are usually benign slow-growing tumors, derived from leptomeninges. First line treatment for meningiomas surgery. They occasionally difficult to treat surgically because their location, associated vascular nerve structures patient comorbidities. Stereotactic (SRS) option manage these cases. Objective: This studi retrospective, Novembner 2013 January 2018 (4 years), SRS meningioma X-Knife Unit, Neurosurgery Service prof. Kurti UC, Mother Theresa,, Tirana. During this period we evaluated long term effect on tumor control. Material Methods: We analyzed data 17 14 patinets meningiomatosis) variables: age, presenting symptoms, intracranial location meningiomas, surgery prior SRS, extension resection, dose, volume coverage, pre-SRS volume, latest follow up MR biopsy results, Assessment control based VOLUMETRIC criteria RECIST criteria. Results: patients total (17 4 them meningiomatosis), (Male (23%), Female 13 (77%), Age 45-75 years (average 59.5 Median 62.0). Follow (23 months), (Range 59.9-99 99.5), localization meningiomas: Medial sphenoid crystal – 8, Convection 7, Falx/Parasagittal 2. Residual - (24%), Recurence 5 (29%), New 8 (47%), WHO I II III 1 (7%). With out 4. Prescripted dose 14-16 Gy, coverage 59 100%, (91.70), median 95.40, 0.27 10.36 cc (3.84), 1-isocenter 9 cases, 2-isocenter Number arcs isocenter 1-5. Tumor controlled 12 (70%), reduced 22 (48%) (PR), unchanged 7 (SD), adult (WHO 2 3) (PD), side effects 0. 2-51 months months) Mean MRI 0.31 cm3 maximum Diameter over 4.83 cm. According Volumetric (adapted version), remained stable disease excellent 70% total, 100% grade WHO). Conclusions: one safest most effective strategies keep under management different patients, both those with primary tumors relapses or left previous interventions. Doing comparative analysis shows improved long-term SRS. used during evaluation standardization make possible duration